A history of repeated chronic infections due to an acquired B-cell deficiency and decreased antibody production and/or function is usually indicative of
A) AS.
B) polymyositis.
C) common variable immunodeficiency disease (CVID).
D) DiGeorge's anomaly.

Question

Quizplus · Accepted Answer

CVID is an acquired B-cell deficiency that results in decreased antibody production and/or function. The person with CVID has a history of chronic or recurrent infections. The number of circulating B-cells is often normal, but the ability of the B-cells to produce all types of immunoglobulins is reduced. Although the use of immunoglobulin has improved the prognosis, patients often succumb to chronic lung disease or malignancies. Lower levels of immunoglobulin and a lower percentage of B-cells are associated with a poorer prognosis.

A History of Repeated Chronic Infections Due to an Acquired