An Adolescent Is Prescribed Tretinoin (Retin-A Cream) as Therapy for Acne

An adolescent is prescribed tretinoin (Retin-A cream) as therapy for acne. What should the nurse instruct the patient about this medication?

A) Avoid unprotected sun exposure.
B) Apply the cream while the face is wet.
C) Avoid using the medication prior to bedtime.
D) Avoid applying the cream directly on lesions.