What Is True of Evidence-Based Medicine? Select All That Apply

What is true of evidence-based medicine? Select all that apply.

A) Evidence-based medicine has become integral to the best practices in health care.
B) At the heart of evidence-based medicine is the scientific method, which drives the formulation of quality research questions and hypotheses.
C) Evidence-based medicine aims to incorporate epidemiological evidence with systematic reviews of randomized controlled trials to achieve treatment strategies that are based on objective evidence.
D) Evidence-based medicine is influenced by both the business of pharmaceuticals and is distinguished by the effective use of clinical data to integrate patient information, test results, and contemporary research.