Sustained activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to sustained release of ________, which inhibits the production of certain immune cells.

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Cortisol is a glucocorticoid hormone released from the adrenal cortex in response to ACTH, which is produced by the pituitary gland in response to CRH from the hypothalamus. Sustained activation of the HPA axis leads to prolonged cortisol release, which has immunosuppressive effects, including the inhibition of immune cell production.

Sustained Activation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis Leads to Sustained