In humans, old, worn out erythrocytes are destroyed in the _____ and their replacements are derived from _____ residing in the _____.

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Old, worn-out erythrocytes (red blood cells) are primarily destroyed in the spleen, a process known as eryptosis. The replacements for these cells come from pluripotent stem cells, which are capable of differentiating into various types of cells, including erythrocytes. These pluripotent stem cells reside in the bone marrow, specifically the red marrow, which is the site of new blood cell formation, including erythrocytes.

In Humans, Old, Worn Out Erythrocytes Are Destroyed in the _____