Fluoxetine (Prozac) is a serotonin re-uptake inhibitor. Serotonin is generally an excitatory neurotransmitter; therefore, one would expect using fluoxetine to result in ___________ in the post-synaptic neuron.

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Quizplus · Accepted Answer

Fluoxetine, by inhibiting the reuptake of serotonin, increases the amount of serotonin available in the synaptic cleft. This prolongs the action of serotonin on its receptors, leading to graded potentials of longer duration in the post-synaptic neuron.

Fluoxetine (Prozac) Is a Serotonin Re-Uptake Inhibitor