The Main DISADVANTAGE of Excessive Gluconeogenesis During Prolonged Postabsorptive Periods

The main DISADVANTAGE of excessive gluconeogenesis during prolonged postabsorptive periods is that

A) continued protein breakdown can impair enzymatic activity and plasma membrane functions.
B) carbohydrate buildup in the liver impairs its function.
C) the brain is exposed to levels of glucose that are too high.
D) tissues other than the brain increase glucose utilization.
E) glucose absorption from the gut is impaired.