Transfer of a Functional Domain from One Gene to Another

Transfer of a functional domain from one gene to another, creating a novel protein, can occur by ________; this could provide an evolutionary advantage because

A) intron realignment; it shifts protein structure.
B) intron shuffling; it increases genetic variation in a population.
C) exon shuffling; it increases genetic variation in a population.
D) proteomics; it shifts protein structure.
E) both intron shuffling and proteomics; it shifts protein structure and increases genetic variation.