By lacking an essential serine or tyrosine, proteins with pseudosubstrate domains regulate signaling pathways by blocking kinase

Question

Quizplus · Accepted Answer

Pseudosubstrate domains mimic the substrate of a kinase but lack the critical serine or tyrosine residue necessary for phosphorylation. This prevents the kinase from transferring a phosphate group to the pseudosubstrate, effectively blocking the kinase's ability to phosphorylate its actual substrates.

By Lacking an Essential Serine or Tyrosine, Proteins with Pseudosubstrate