The Thermodynamic Stabilization of the Protein in Folded State Is

The thermodynamic stabilization of the protein in folded state is partly due to the hydrophobic effect that accompanies protein folding. The hydrophobic effect in proteins is manifested in ________ and _________.

A) burial of the hydrophilic side chains; release of the water molecules
B) burial of the exposed hydrophobic side chains; release of the solvating water molecules
C) release of the water molecules; solvation of cations
D) release of the water molecules; formation of salt bridges
E) none of the above