Models of allosterism describe the conformational change between the tense (T; low affinity) and the relaxed (R; high affinity) states of protein structure. These include a concerted model, in which subunits of proteins transition between T and R states one at a time, and a sequential model, where all subunits transition between the T and R states at the same time, as regulators bind.

Question

Quizplus · Accepted Answer

The first sentence accurately describes the concept of allosterism and the existence of tense (T) and relaxed (R) states in proteins. However, the second sentence inaccurately describes the concerted and sequential models. In the concerted model, all subunits switch between T and R states simultaneously, not one at a time. In the sequential model, subunits can transition between states individually as regulators bind, not all at once.

Models of Allosterism Describe the Conformational Change Between the Tense