An Antagonist and an Inverse Agonist Are Similar in That

An antagonist and an inverse agonist are similar in that

A) both bind the receptor ligand-binding site
B) with both, the cellular effect is similar to the absence of natural ligand
C) with both, the receptor is irreversibly blocked
D) both lower the ability of the natural ligand to bind due to conformational changes to the receptor
E) None of the above is correct