Typically, addition of a(n) _____ group to certain lysine residues of a histone protein makes the region of chromatin transcriptionally _____; addition of a(n) _____ group to certain lysine residues makes the region of chromatin transcriptionally _____.

Question

Quizplus · Accepted Answer

Acetylation of lysine residues on histones relaxes the chromatin structure, making the DNA more accessible to transcription factors and RNA polymerase, thus promoting gene expression. Methylation of lysine residues can have either an activating or repressive effect on gene expression, depending on the specific residue that is methylated.

Typically, Addition of A(n) _____ Group to Certain Lysine Residues