A College Student Is in an Outpatient Clinic for a Routine

A college student is in an outpatient clinic for a routine gynecologic examination. When taking the patient's history, which information is most significant?

A) "I have had such lumpy breasts lately, especially before my periods."
B) "Lately I have noticed that the area around my right nipple has a rash that is sore and itchy all the time."
C) "It seems like a week and a half before my period I get a whitish yellow vaginal discharge."
D) "How come I get a really bad side ache for about a day in the middle of every cycle?"