The presence of heterophile antibodies, rheumatoid factor, increased blood levels of hemoglobin and circulating cTnI autoantibodies can result in which of the following?
A) High dose hook effect with select cTn assays
B) Modification of diagnostic cut off value for cTn assays
C) False positive and/or false negative result for BNP or NT-Pro BNP assays
D) False positive and/or false negative result for cTnI assays

Question

Quizplus · Accepted Answer

The presence of heterophile antibodies, rheumatoid factor, increased blood levels of hemoglobin, and circulating cTnI autoantibodies can interfere with cardiac troponin I (cTnI) assays, potentially leading to false positive or false negative results. These substances can affect the assay's accuracy by interfering with the antigen-antibody reaction that is the basis of the test.

The Presence of Heterophile Antibodies, Rheumatoid Factor, Increased Blood Levels