Although a total lactate dehydrogenase (LD) determination performed alone yields little information as to the area of tissue destruction, an electrophoretic separation of LD isoenzyme may be useful. With what disorder is an increase in LD-5 and LD-4 associated?
A) Acute hepatic disease
B) Acute myocardial infarction
C) Pulmonary infarction
D) Pancreatitis

Question

Quizplus · Accepted Answer

An increase in LD-5 and LD-4 isoenzymes is associated with acute hepatic disease. LD isoenzymes vary in concentration in different tissues, and the pattern of elevation can help identify the tissue of origin of the damage. LD-5 and LD-4 are most abundant in the liver, thus their elevation is indicative of hepatic damage.

Although a Total Lactate Dehydrogenase (LD) Determination Performed Alone Yields