Which of the following patients is most likely to benefit from transplantation of thymic tissue or major histocompatibility complex (MHC)-compatible bone marrow?
A) A 12-year-old girl with a history of epilepsy and low IgG levels secondary to phenytoin use
B) A 7-year-old boy whose blood work indicates decreased IgA and IgG with increased IgM
C) A 6-year-old boy whose pre-B cells are incapable of translation to normal B cells
D) A 9-year-old girl who has a diagnosis of IgA deficiency

Question

Quizplus · Accepted Answer

Decreased IgA, IgE, and IgG with increased IgM levels are characteristic of X-linked immunodeficiency with hyper-IgM, a primary cell-mediated immunodeficiency that would respond to thymic tissue transplantation and MHC-compatible bone marrow. Low IgG levels secondary to phenytoin use, X-linked hypogammaglobulinemia, and selective IgA deficiency are unlikely to be treated with the T-cell-focused treatments like thymic tissue transplantation and MHC-compatible bone marrow.

Which of the Following Patients Is Most Likely to Benefit