Following a spider bite she received while camping, a 20-year-old female presented to the emergency department with rash, edema, and fever and was subsequently diagnosed with serum sickness. Which of the following statements best conveys the physiological rationale for the broad systemic effects of this event?
A) The woman is experiencing diffuse tissue necrosis as a consequence of an Arthus reaction.
B) Antigen-antibody complexes have been deposited in a variety of locations throughout the body.
C) Antibody binding to specific target cell receptors is bringing about a change in cell function.
D) Deposited antibodies are activating her complement system.

Question

Quizplus · Accepted Answer

Serum sickness is characterized by the deposition of antigen-antibody complexes in blood vessels, joints, heart, and kidney tissue. The deposited complexes activate complement, increase vascular permeability, and recruit phagocytic cells, all of which can promote focal tissue damage and edema. Serum sickness is not synonymous with an Arthus reaction. Antibody binding to specific target cell receptors causing a change in cell function is characteristic of antibody-mediated cellular dysfunction. Serum sickness is not associated with the activation of the complement system.

Following a Spider Bite She Received While Camping, a 20-Year-Old