Which of the following phenomena contributes to the difficulties with absorption, distribution, and elimination of drugs that are associated with kidney disease?
A) Reductions in plasma proteins increase the amount of free drug and decrease the amount of protein-bound drug.
B) Acute tubular necrosis is associated with impaired drug reabsorption through the tubular epithelium.
C) Decreased retention by the kidneys often renders normal drug dosages ineffective.
D) Dialysis removes active metabolites from circulation minimizing therapeutic effect.

Question

Quizplus · Accepted Answer

A decrease in plasma proteins, particularly albumin, that occurs in many persons with renal failure results in less protein-bound drug and greater amounts of free drug. Drug elimination problems do not stem as directly from impaired tubular reabsorption, decreased retention, or the process of dialysis.

Which of the Following Phenomena Contributes to the Difficulties with Absorption