Due to Her Progressing Osteoarthritis (OA), an 80-Year-Old Woman Is

Due to her progressing osteoarthritis (OA) , an 80-year-old woman is no longer able to perform her activities of daily living without assistance. Which of the following phenomena most likely underlies the woman's situation?

A) Inappropriate T-cell-mediated immune responses have resulted in articular cartilage degeneration.
B) Loss of articular cartilage and synovitis has resulted from inflammation caused when joint cartilage attempted to repair itself.
C) Excessive collagen deposits have accumulated in the woman's synovial joints.
D) Bone overgrowth in synovial joints has resulted in fusing of adjacent bones that normally articulate.