The Clearance of Drugs from the Bodies of Most Older

The clearance of drugs from the bodies of most older patients is slower than that of younger adults and children. As a result older patients usually need:

A) A bolus of a medication followed by a maintenance dose of the drug
B) To begin any new medication at a lower dose than a younger patient of the same body weight
C) To begin any new medication at a higher dose than a younger patient of the same body weight
D) To combine their medications with herbal medications which enhance drug metabolism and clearance