Nicotine causes liver microsomal enzymes to increase the rate of deactivation of drugs and thus decrease the clinical effects of the benzodiazepines and some antidepressants and analgesics.

Question

Quizplus · Accepted Answer

Nicotine induces the activity of certain liver enzymes (cytochrome P450 enzymes, specifically CYP1A2), which can lead to increased metabolism (deactivation) of various drugs, including some benzodiazepines, antidepressants, and analgesics, thereby potentially reducing their effectiveness.

Nicotine Causes Liver Microsomal Enzymes to Increase the Rate of Deactivation