The nurse cares for patients who receive propofol extended [Diprivan]. What are important nursing considerations for these patients?

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Propofol can cause profound respiratory depression. It has a relatively narrow therapeutic range and can cause death from respiratory arrest. Facilities for respiratory support should be immediately available. Propofol infusion syndrome may occur in patients receiving prolonged, high-dose infusion, and CPK levels should be monitored and the drug should be stopped if they are greater than 5000 U/L. Propofol can cause transient pain at the IV site, which can be minimized by injecting IV lidocaine at the site just before injecting. The infusion rate should never be greater than 4 mg/kg/hr. There is a high risk of bacterial infection, so opened vials need to be discarded within 6 hours.

The Nurse Cares for Patients Who Receive Propofol Extended [Diprivan]