In the muscle, when a residue of glucose is cleaved from glycogen and converted to pyruvate via glycolysis, what is the net ATP production?

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Quizplus · Accepted Answer

When glucose is cleaved from glycogen, it enters glycolysis as glucose-1-phosphate, which is converted to glucose-6-phosphate without consuming ATP. This saves one ATP compared to free glucose entering glycolysis. Glycolysis then produces 4 ATP and consumes 1 ATP (since the initial ATP investment is bypassed), resulting in a net gain of 3 ATP.

In the Muscle, When a Residue of Glucose Is Cleaved