Which of the Following Best Explains the Energetically Favorable Formation $\Delta$

Which of the following best explains the energetically favorable formation of UDP-glucose in the liver and muscle?

A) $\Delta$ G°' for the reaction glucose-1-phosphate + UTP $\rarr$ UDP-glucose + PP_i is very negative.
B) $\Delta$ G°' for the reaction glucose-1-phosphate + UTP $\rarr$ UDP-glucose + PP_i is very positive.
C) $\Delta$ phosphoglucoisomerase°' for the reaction PP_i $\rarr$ 2P_i is very negative.
D) $\Delta$ G°' for the reaction PP_i $\rarr$ 2P_i is very positive.
E) $\Delta$ G°' for the overall reaction is very positive.