Creation of which of the following does not rely on homologous recombination into the genome?

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Transgenic mice are created by introducing foreign DNA into their genome, typically using methods such as microinjection into pronuclei of fertilized eggs, which does not rely on homologous recombination. Knockout, knockin, and conditional knockout mice all involve specific modifications to the genome that rely on homologous recombination to target a specific gene for deletion, insertion, or conditional expression.

Creation of Which of the Following Does Not Rely on Homologous