During V(D)J recombination there is epigenetic control of the initial selection of the allele to be rearranged. This involves

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During V(D)J recombination, epigenetic mechanisms such as histone acetylation, DNA methylation, and replication timing play crucial roles in the selection of alleles for rearrangement. These mechanisms ensure that only one allele undergoes rearrangement at a time, a process known as allelic exclusion, which is essential for generating a functional and diverse repertoire of antigen receptors. Progressive histone hyperacetylation can make chromatin more accessible for the rearrangement machinery, differential methylation can mark one allele for rearrangement while protecting the other, and early replication can indicate which allele is to be rearranged first.

During V(D)J Recombination There Is Epigenetic Control of the Initial