During rearrangement of immunoglobulin genes there is epigenetic control of the initial selection of the allele to be rearranged, as well as maintenance of allelic exclusion. You determine that both light chain alleles in pre-B cells have hyperacetylated histones, but one allele is methylated and late-replicating and the other allele is unmethylated and early replicating. Which allele is likely to be subject to rearrangement? Explain your answer.

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The Answer of During rearrangement of immunoglobulin genes there is epigenetic control of the initial selection of the allele to be rearranged, as well as maintenance of allelic exclusion. You determine that both light chain alleles in pre-B cells have hyperacetylated histones, but one allele is methylated and late-replicating and the other allele is unmethylated and early replicating. Which allele is likely to be subject to rearrangement? Explain your answer.

During Rearrangement of Immunoglobulin Genes There Is Epigenetic Control of the Initial