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You Have Made a Transgenic Mouse Using a CDNA Coding

Question 47

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You have made a transgenic mouse using a cDNA coding for a human protein under
control of a heterologous promoter. In most of the transgenic mice, you observe position-dependent expression of the human protein. Define the term "position-dependent" and
give examples of regulatory regions that you could link to the promoter-human
cDNA construct that might confer position-independent expression. Explain your choice of regulatory regions.

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Position-dependent expression refers to ...

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