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During DNA Replication, DNA Ligase Is Most Active on the Lagging

Question 6

Multiple Choice

During DNA replication, DNA ligase is most active on the lagging strand. This is because:


A) The lagging strands contain more short DNA segments than the leading strand, and these short segments are ligated together with DNA ligase.
B) The lagging strand is synthesized in the 3 ' to 5 ' direction.
C) The lagging strand requires DNA ligase to couple the RNA primer to the Okazaki fragments.
D) The lagging strand is synthesized more slowly, and DNA ligase acts as a sliding clamp to speed up the DNA polymerase.

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