Replacing an A with a T in a hemoglobin gene is associated with sickle-cell anemia in humans.
Normal: 5′-ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3′
Sickle cell: 5′-ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3′
(a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA?
(b) What is the amino acid sequence in this part of the polypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin?
(c) Why might this amino acid substitution make a difference in protein structure?

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The Answer of Replacing an A with a T in a hemoglobin gene is associated with sickle-cell anemia in humans.
Normal: 5′-ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3′
Sickle cell: 5′-ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3′
(a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA?
(b) What is the amino acid sequence in this part of the polypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin?
(c) Why might this amino acid substitution make a difference in protein structure?

Replacing an a with a T in a Hemoglobin Gene