In the Development of a Group Support System, Cultural Differences

In the development of a Group Support System, cultural differences among users may bring interface design issues such as:

A) users' cultural background would decide their left/right hand preference in system use;
B) the volume of a sound element in the interface should be set differently according to various users' cultural background;
C) the meaning of the an icon (or symbol) need to be defined differently for users from different cultures;
D) the same color may have different connotations in different cultures;
E) users' preference in the size display of is directly associated with their background culture.