What contributes to drug resistance to chemotherapeutic agents?

Name: What contributes to drug resistance to chemotherapeutic agents?
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Drug resistance can occur by cellular production of a drug transport molecule, known as P-glycoprotein, that can transport the drug out of the cell; creation of selection pressure by favoring drug-resistant mutant cells; and reduction of target molecule sensitivity. Drug resistance does not occur by drug-induced mutation or increased drug uptake by tumor cells.

What Contributes to Drug Resistance to Chemotherapeutic Agents