One of the infamous experiments that lead to the development of Institutional Review Boards was the:

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The Tuskegee Experiment was a study conducted between 1932-1972 by the U.S. Public Health Service to observe the natural progression of untreated syphilis in African American men. The participants were never informed of their diagnosis nor were they treated, even when effective treatments became available. The unethical nature of this experiment led to the establishment of guidelines and regulations for the protection of human research participants, including the creation of Institutional Review Boards.

One of the Infamous Experiments That Lead to the Development