In pemphigus the blistering generally occurs _______________while in pemphigoid the bullae (blisters) are ______________.

Question

Quizplus · Accepted Answer

In pemphigus, blistering occurs within the epidermis (intraepidermally) due to autoantibodies against desmosomes, which are adhesion proteins that hold skin cells together. In pemphigoid, the blisters form beneath the epidermis (subepidermal) because of autoantibodies targeting hemidesmosomes, which connect the basal cells of the epidermis to the basement membrane.

In Pemphigus the Blistering Generally Occurs _______________While in Pemphigoid the Bullae