A major embryonic signaling center,producing fibroblast growth factor-8 and Wnt-1 and inducing gradients of En-1 and En-2,is located at the ____________.

Question

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The midbrain-hindbrain junction is a major embryonic signaling center that produces fibroblast growth factor-8 (FGF8) and Wnt-1, which play important roles in early neural development. This signaling center also induces gradients of En-1 and En-2, which are transcription factors involved in patterning the midbrain and hindbrain regions. Hensen's node is important in the establishment of the dorsal-ventral axis of the embryo. The notochord is important in the formation of the neural tube and the development of the axial skeleton. The prechordal plate is important in the formation of the forebrain.

A Major Embryonic Signaling Center,producing Fibroblast Growth Factor-8 and Wnt-1