A newborn exhibits multiple congenital defects including a cleft palate,deafness,ocular hypertelorism,and a white forelock but otherwise dark hair on his head.The probable diagnosis is ________________________:

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The combination of cleft palate, deafness, ocular hypertelorism, and a white forelock is characteristic of Waardenburg syndrome, an autosomal dominant genetic disorder that affects neural crest cell development. The dark hair on the head is due to a separate gene variant called KIT. Von Recklinghausen's disease is also known as neurofibromatosis type 1 and is characterized by tumors growing along nerves. Hirschsprung's disease is a congenital disorder of the colon causing bowel obstruction. Klinefelter syndrome is a chromosomal disorder in which males have an extra X chromosome, resulting in hypogonadism and often infertility. Arnold-Chiari malformation is a brain abnormality in which the cerebellum extends into the spinal canal.

A Newborn Exhibits Multiple Congenital Defects Including a Cleft Palate,deafness,ocular