Which family of molecules is heavily involved in patterning along the (proximodistal)length of the embryonic mandible?

Question

Quizplus · Accepted Answer

The Dlx family of homeobox-containing genes is heavily involved in patterning along the proximodistal length of the embryonic mandible. They are expressed in specific domains of the developing mandible and play a critical role in the differentiation and proliferation of mandibular mesenchyme. Mutations in DLX genes have been associated with craniofacial abnormalities, such as cleft lip and palate. Otx genes are involved in the development of the forebrain and midbrain. Hedgehog signaling is important in many aspects of embryonic development, but does not play a direct role in mandibular development. Msx genes are more involved in patterning specific structures within the mandible, but not in regulating proximodistal length.

Which Family of Molecules Is Heavily Involved in Patterning Along