You Are Caring for a Patient with Sickle Cell Disease

You are caring for a patient with sickle cell disease in her home. Over the years, there has been joint damage, and the patient is in chronic pain. The patient has developed a tolerance to her usual pain
Medication. When does the tolerance to pain medication become the most significant problem?

A) When it results in inadequate relief from pain
B) When dealing with withdrawal symptoms resulting from the tolerance
C) When having to report the patients addiction to her physician
D) When the family becomes concerned about increasing dosage