Familial Retinoblastoma

Familial retinoblastoma

A) susceptibility is inherited as a recessive trait.
B) differs from non-familial retinoblastoma in that there is no recurrence in the familial form.
C) always leads to the development of tumours, usually later in life.
D) is caused primarily by acquired mutations in both alleles.
E) is caused by inheritance of a non-functional allele, plus mutation of the second allele.