The Wrapping of DNA into Nucleosomes Hinders Transcription by RNA

The wrapping of DNA into nucleosomes hinders transcription by RNA polymerase. To allow transcription

A) RNA polymerase in eukaryotes contains an exonuclease activity which allows the enzyme to transcribe DNA in nucleosomes.
B) activation complexes often contain enzymes that remove acetyl groups from histones.
C) acetyl groups are added to histone proteins, making them less positively charges and reducing the strength with which they bind to DNA.
D) enhancer-binding proteins contain a protease to degrade histone proteins and make the DNA more accessable.
E) a regulatory cascade ensures that transcription is coordinately regulated with the first protein product being an enzyme to remove histones from DNA.