The compound 2,4-dinitrophenol (DNP) destroys the proton concentration gradient across the inner mitochondrial membrane. If isolated mitochondria are incubated in a solution of DNP, you would expect

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DNP uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane, which is necessary for ATP synthesis. Thus, ATP cannot be generated efficiently.

The Compound 2,4-Dinitrophenol (DNP) Destroys the Proton Concentration Gradient Across