Which of the Following Statements About Transmembrane Channels That Open

Which of the following statements about transmembrane channels that open and close is true?

A) Ligand-gated channels open in response to mechanical force.
B) Voltage-gated channels open when the charge difference across a membrane decreases.
C) Ligand-gated channels close in response to specific ligands binding.
D) Voltage-gated channels open when the charge inside a cell becomes more negative.
E) Mechanically gated channels are mechanosensitive and open in response to depolarisations.