Sickle-cell anemia is a disease whose phenotype includes not only anemia, but also damage to many different organs. All phenotypes, however, can be traced to a single gene. This is an example of :

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Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic traits, which is the case with sickle-cell anemia where a single gene mutation affects various organs and causes anemia.

Sickle-Cell Anemia Is a Disease Whose Phenotype Includes Not Only