Premenstrual dysphoric disorder (PMDD) is differentiated from PMS by depression that interferes with occupational and social functioning.

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PMDD is a more severe form of premenstrual syndrome (PMS) characterized by significant premenstrual mood disturbance, often with marked depression, irritability, and tension that significantly interferes with a woman's ability to function in her daily life, including occupational and social functioning.

Premenstrual Dysphoric Disorder (PMDD) Is Differentiated from PMS by Depression