Which of the following statements correctly compares and contrasts a-priori and a-posteriori methods of reference individual selection?
1)In both methods, exclusion and partitioning take place after sampling and analyte testing.
2)A-priori methods require fewer reference individuals to be studied than a-posteriori methods.
3)Questionnaires for potential reference individuals must be more detailed for a-posteriori methods than for a-priori methods.

Question

Quizplus · Accepted Answer

The a-priori method of selecting reference individuals is a method that is best suited for use with laboratory methods that are established and well studied.There is less background research associated with this method, because much information is already known about it.Thus well-defined exclusion and partitioning criteria can be established before the selection of reference individuals.Because of this background and knowledge regarding these methods, fewer samples are required for the development of the reference interval; essentially, the number of samples necessary for the results to be statistically valid.The a-posteriori method is more useful for new or poorly studied laboratory methods.With less information being known about these methods, research must be more extensive, although the literature typically contains little information.Thus the questionnaire for this method must be more extensive, and a larger number of samples will be required.Also, in this method, exclusion and partitioning of participants usually occurs after sampling and analysis.

Which of the Following Statements Correctly Compares and Contrasts A-Priori