Hemodialysis or Hemoperfusion May Be Effective in Removing Water-Soluble Toxins

Hemodialysis or hemoperfusion may be effective in removing water-soluble toxins that have which of the following characteristics?
1) high molecular weight
2) low volume of distribution
3) low protein binding

A) 1, 2, 3
B) 2, 3
C) 1, 3
D) 1, 2