A 29 -year-old woman presents with a $101^{\circ} \mathrm{F}$ fever, pericardial effusions and Libman-Sachs endocarditis, arthralgia, and facial rash across the malar region ("butterfly rash") that is accentuated by sun exposure. Laboratory tests show creatine $1.7 \mathrm{mg} / \mathrm{dL}$ (normal 0.5-1.1 $\mathrm{mg} / \mathrm{dL}$ ), high titers of antinuclear autoantibodies (ANA), Smith antigen, and antinucleosome antibodies in the blood. Which one of the following is most likely to be directly affected by the disruption of nucleosomes in this patient?

Question

Quizplus · Accepted Answer

Nucleosomes are responsible for packaging genetic material in a condensed form, so disruption would affect this process.

A 29 -Year-Old Woman Presents with A 101∘F101^{\circ} \mathrm{F}101∘F Fever, Pericardial Effusions and Libman-Sachs Endocarditis, Arthralgia, and Facial Rash

A 29 -Year-Old Woman Presents with A $101^{\circ} \mathrm{F}$ Fever, Pericardial Effusions and Libman-Sachs Endocarditis, Arthralgia, and Facial Rash