A 15-year-old male presents with hematuria, hearing loss, lens dislocation, and the onset of cataracts. Genetic analysis reveals a mutation in the COL4A5 gene. Transmission EM examination of a renal biopsy confirms that the disorder has affected a component of the renal corpuscles in which damage disrupts normal glomerular filtration. Which one of the following structures would most likely be abnormal in the TEM of this patient's biopsy?

Question

Quizplus · Accepted Answer

The COL4A5 gene mutation is associated with Alport syndrome, which affects the glomerular basement membrane, leading to its abnormal structure and function.

A 15-Year-Old Male Presents with Hematuria, Hearing Loss, Lens Dislocation