A 9-year-old girl, the youngest of four daughters, is taken to the pediatrician by her mother, who indicates that for at least 4 months the child has seemed "hyperactive," unable to sleep soundly because "she says her room is too hot," and no longer able to concentrate in school. Upon questioning, the mother also remembers that her daughter's periods also began within the past few months. Blood tests indicate high levels of estrogen-related hormones and cortisol. Which of the following tentative diagnoses is consistent with all of these symptoms?

Question

Quizplus · Accepted Answer

A benign tumor involving cells in the adenohypophysis (pituitary gland) could lead to increased production of ACTH, causing elevated cortisol levels, and potentially increased production of other hormones affecting estrogen levels, explaining the early puberty and hyperactivity symptoms.

A 9-Year-Old Girl, the Youngest of Four Daughters, Is Taken